Z-disc Protein Interactions Scheme • Scientific Illustration

We have recently created an illustrated model of Z-disc proteins and their interactions for the research group of Prof. Kristina Djinovic-Carugo. We have decided to open the illustrations for your use under under a Creative Commons license. Read the terms of use below.

Z-disc-interactions-color

Z-disc (Z-line or Z-body) is a protein structure bounding the basic unit of striated muscle tissue, a sarcomere. The core of a Z-disc consists of actin filaments coming from adjacent sarcomeres which are crosslinked by α-actinin molecules. In electron micrographs of cross-striated muscle, Z-discs appear as a series of characteristic dark lines [1, 2].

Z-disc is primarily important for mechanical stability of muscle tissue, but Z-disc proteins and their interacting partners also play a role in intracellular signalling, mechanosensation, mechanotransduction, protein turnover, and autophagy. Mutations in Z-disc proteins lead to a diverse group of muscle diseases, such as various cardiomyopathies, muscular dystrophies, and myofibrillar myopathy [1, 2].


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