Z-disc Protein Interactions Scheme • Scientific Illustration
Z-disc (Z-line or Z-body) is a protein structure bounding the basic unit of striated muscle tissue, a sarcomere. The core of a Z-disc consists of actin filaments coming from adjacent sarcomeres which are crosslinked by α-actinin molecules. In electron micrographs of cross-striated muscle, Z-discs appear as a series of characteristic dark lines [1, 2].
Z-disc is primarily important for mechanical stability of muscle tissue, but Z-disc proteins and their interacting partners also play a role in intracellular signalling, mechanosensation, mechanotransduction, protein turnover, and autophagy. Mutations in Z-disc proteins lead to a diverse group of muscle diseases, such as various cardiomyopathies, muscular dystrophies, and myofibrillar myopathy [1, 2].
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